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London: University of OxfordS Covit-19 vaccine candidate The two full-dose regimens have better immunity when used than the full dose following a half-dose booster, the university said Thursday, citing data from early trials.
Developers of the vaccine candidate, which is licensed to the pharmaceutical company Astrogenogen, Have already published post-test results showing higher efficacy when half-dose is followed by a full dose, compared with the two full-dose regime. However, more work needs to be done to confirm that decision.
The latest details of Phase I and 2 clinical trials released on Thursday made no mention of the half-dose / full-dose regime, which Oxford said was “unplanned” but approved by regulators.
American pharmaceutical maker Pfizer has overtaken the British team as a pioneer in the development of a corona virus vaccine, whose footage has been rolled out. Britain And United Nations This month.
Data previously released from Phase 3 trials then showed that test participants were given two full doses of 62%, but a small subgroup was given 90% of the first half, and then a full dose.
In its report on Thursday, the university said it had examined two potent regimes in early phase trials, a full-dose / full-dose regime and a full-dose / half-dose regime, which was investigated as a “dose sparring” strategy.
“Both booster doses of the vaccine have been shown to induce stronger antibody responses than a single dose, with a standard dose / standard dose triggering a better response,” the university said in a statement.
The vaccine “stimulates broad-spectrum antibody and T-cell activity,” it said.
Developers of the vaccine candidate, which is licensed to the pharmaceutical company Astrogenogen, Have already published post-test results showing higher efficacy when half-dose is followed by a full dose, compared with the two full-dose regime. However, more work needs to be done to confirm that decision.
The latest details of Phase I and 2 clinical trials released on Thursday made no mention of the half-dose / full-dose regime, which Oxford said was “unplanned” but approved by regulators.
American pharmaceutical maker Pfizer has overtaken the British team as a pioneer in the development of a corona virus vaccine, whose footage has been rolled out. Britain And United Nations This month.
Data previously released from Phase 3 trials then showed that test participants were given two full doses of 62%, but a small subgroup was given 90% of the first half, and then a full dose.
In its report on Thursday, the university said it had examined two potent regimes in early phase trials, a full-dose / full-dose regime and a full-dose / half-dose regime, which was investigated as a “dose sparring” strategy.
“Both booster doses of the vaccine have been shown to induce stronger antibody responses than a single dose, with a standard dose / standard dose triggering a better response,” the university said in a statement.
The vaccine “stimulates broad-spectrum antibody and T-cell activity,” it said.
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